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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10990/775

Autori: De Col, Valentina
Supervisore afferente all'Università: ZANCANI, MARCO
Titolo: Structure and function of the Permeability Transition Pore (PTP) in plant mitochondria
Abstract (in inglese): Mitochondria are multifunctional organelles with a crucial role in bioenergetics, being the major generators of ATP in the cell. The energetic machinery is responsible for a tightly controlled process, but in some cases it can encounter a sudden disruption through the opening of the mitochondrial permeability transition pore (PTP). The identity of PTP has not been completely unravelled yet, and it represents one of the most elusive topics in cell biology. The current idea is that PTP coincides with mitochondrial proteins of major importance, preserved through evolution. In the controversial scenario of molecular attributions for PTP, F-ATP synthase dimers were recently suggested and proved to be one strong candidate for the PTP in mammals, yeast and flies. This work aims to investigate if this model could also be applied to plant mitochondria, where no evidence has been collected so far. In this scenario, F-ATP synthase might represent an enzyme with multiple functions: shaping mitochondrial cristae architecture, sustaining life through ATP production and becoming also a permeability system, hence controlling life and death processes. In this ‘three-paper dissertation’ we reviewed the literature on PTP in plants, collected new evidence on permeability transition (PT) and PTP in isolated pea mitochondria and established a novel methodology for monitoring ATP levels and dynamics with the fluorescent protein sensor ATeam
Parole chiave: Permeability transition pore; PTP, Plant mitochondria
MIUR : Settore BIO/04 - Fisiologia Vegetale
Lingua: eng
Data: 17-mar-2017
Corso di dottorato: Dottorato di ricerca in Scienze e biotecnologie agrarie
Ciclo di dottorato: 29
Università di conseguimento titolo: Università degli Studi di Udine
Luogo di discussione: Udine
Citazione: De Col, V. Structure and function of the Permeability Transition Pore (PTP) in plant mitochondria. (Doctoral Thesis, Università degli Studi di Udine, 2017).
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